Characterization of the synthetic cannabinoid MDMB-CHMCZCA

• Carina Weber,
• Stefan Pusch,
• Dieter Schollmeyer,
• Sascha Münster-Müller,
• Michael Pütz and
• Till Opatz

Beilstein J. Org. Chem. 2016, 12, 2808–2815, doi:10.3762/bjoc.12.279

• Chiralpak IA-3 column (length: 25 cm, diameter: 4.6 mm, particle size: 3 μm; Daicel) was used at a temperature of 40 °C. Synthetic cannabinoids JWH-018 (1), MDMB-CHMICA (2), MDMB-CHMCZCA (3), and EG-018 (4). Molecular structure of (S)-MDMB-CHMCZCA (3) with numbering scheme. ESI-MSn pattern of 3 (m/z values

• and comparison of the data with DFT calculations, while ECD spectroscopy was found to be inconclusive in this case. The enantiomeric purity of samples from test purchases and police seizures was assessed by a self-developed chiral HPLC method. Keywords: chiral HPLC; ECD spectroscopy; NPS; synthetic

• cannabinoids; VCD spectroscopy; Introduction Starting in 2008 with the appearance of “Spice products”, herbal mixtures spiked with synthetic cannabinoid receptor agonists began to spread on the international drug market [1][2]. The cannabimimetic substances are the psychoactive ingredients of those mixtures